After Joe started high school, he started having pain in his joints. The pain became progressively worse. When Joe’s parents took him to the doctor to investigate the pain, they were concerned that it could be leukemia. Because Joe has Downs Syndrome, a genetic disorder that causes developmental and intellectual delays, his parents knew he had a 3% chance of developing leukemia. Despite their suspicions, it was a shock when the doctors confirmed his diagnosis of acute lymphocytic leukemia (ALL). Joe and his parents traveled from Canada to receive months of CAR T-cell treatment at Children’s Hospital of Philadelphia. Throughout Joe’s stay at CHOP, patients, staff and Joe’s Facebook followers looked forward to Joe’s Joke of the Day. The daily ritual helped keep everyone’s spirits up including Joe’s. Fortunately, the treatment worked and at this time there is no sign of leukemia in Joe’s body!